tag:blogger.com,1999:blog-16774010.post6903288406672159288..comments2024-01-25T17:58:34.297-05:00Comments on Scott's Web Log: Biodel Announces Manufacturing Plans for VIAjectâ„¢Scott Shttp://www.blogger.com/profile/03286529314567223617noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-16774010.post-30885969649420301502008-01-07T16:08:00.000-05:002008-01-07T16:08:00.000-05:00I think you may be mistaken. These additives will...I think you may be mistaken. These additives will not be added to insulin analogs, but to regular insulin (the type that was discovered by Banting and Best in 1921). The additives provide the regular human insulin with absorption, distribution, metabolism, and excretion (known as "ADME" profile in pharmaceutical industry lingo) as today's analogs.<BR/><BR/>Note that the issue related to absorption is discussed in the December/January issue of Diabetes Health, but the reality is that the bigger the dose, the longer it takes to be absorbed (analog or not) because of the fact that insulin is dosed subcutaneously rather than directly into the bloodstream as the beta cells would secrete insulin.<BR/><BR/>At present, the adverse effect reporting required by the U.S. Food and Drug Administration (FDA) means that VIAject does not differ substantially from today's analogs and may actually be somewhat safer (at least relative to hypoglycemia) for reasons Biodel disclosed at last year's ADA Scientific Sessions. <BR/><BR/>http://digital.diabeteshealth.com/read/07/12/7.html<BR/><BR/>Note that VIAject is current in Phase III Clinical Trials, so if there are differences we should expect to see them in the trial results to follow.Scott Shttps://www.blogger.com/profile/03286529314567223617noreply@blogger.comtag:blogger.com,1999:blog-16774010.post-22185208144619252262008-01-07T15:46:00.000-05:002008-01-07T15:46:00.000-05:00Has anyone actually thought about whether or not t...Has anyone actually thought about whether or not these additives to the insulin analogs will increase the risk of severe hypoglycemia? I mean, Symilin was supposed to help with this and yet I've had more severe lows while on Symilin than when I was trying to manage my diabetes with insulin (Humulog and Lantus) alone. Have they considered what this product could do to a Type 1 diabetic who has a high, injects this stuff to correct and then has to drive somewhere? Ideally, the diabetic would test before getting behind the wheel, but that's no guarantee that their blood sugar wouldn't quickly go too low for safe driving.Anonymousnoreply@blogger.com