tag:blogger.com,1999:blog-16774010.post4790857019485823410..comments2024-01-25T17:58:34.297-05:00Comments on Scott's Web Log: Lilly RespondsScott Shttp://www.blogger.com/profile/03286529314567223617noreply@blogger.comBlogger9125tag:blogger.com,1999:blog-16774010.post-3995428463579674232007-12-02T02:30:00.000-05:002007-12-02T02:30:00.000-05:00Hello Scott and thanks for sharing the pen debate....Hello Scott and thanks for sharing the pen debate.<BR/>I would love to know if the humapen is conpatable with the lantus vile? As I live in Australia and don't get the humalog insulins here.<BR/>At the moment the lantus uses the Autopen24 which is poor performance pen to use and I hate it as the humapen is so attractive.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-16774010.post-52913749772338787262007-04-04T17:38:00.000-04:002007-04-04T17:38:00.000-04:00Thanks for your comments. You will note that I sa...Thanks for your comments. You will note that I said "many endocrinologists" see hyperinsulinemia as part as part of the problem, rather than the solution to type 2 diabetes but that does not mean those views apply to all. We can safely say that the evidence is conflicting.<BR/><BR/>I should have made it clear that we know type 2 diabetes is a progressive disease meaning that the beta cells will become increasingly impaired over time, and ultimately, these individuals will essentially have the same beta cell function – little or none – as a type 1 patient, which necessitates insulin replacement. But insulin resistance can make replacing that insulin much more of a challenge for these patients, and we know that the dosage for many patients with type 2 is significantly higher per kg of body weight than it is for most with type 1. Skilled clinicians frequently find that insulin must be combined with other drugs for truly effective treatment.<BR/><BR/>In at least one study, high levels of insulin were associated with increased colorectal cancer risk. The association with hyperinsulinemia is also supported by several large clinical studies showing a direct relationship between high insulin levels and cardiovascular risk. Notably, the Paris Prospective Study and the Multiple Risk Factor Intervention Trial (MRFIT) reported positive relationships between insulin levels and atherosclerotic events. In addition, the Veterans Affairs High Density Lipoprotein Intervention Trial (VA-HIT) demonstrated the highest incidence of cardiovascular events in the subgroups with highest levels of insulin. Finally, the landmark Insulin Resistance Atherosclerosis Study (IRAS) provided further evidence for an inverse relationship between carotid intima-medial thickness and insulin sensitivity. The molecular mechanisms are not yet completely understood, and many patients have additional comorbidities such as obesity which complicate matters, but the real key is to measure beta cell function, which can be done with a simple lab test measuring C-peptide.Scott Shttps://www.blogger.com/profile/03286529314567223617noreply@blogger.comtag:blogger.com,1999:blog-16774010.post-80014356798757274872007-04-04T16:57:00.000-04:002007-04-04T16:57:00.000-04:00Scott,Thank you for your devotion to provide an ou...Scott,<BR/><BR/>Thank you for your devotion to provide an outlet for diabetics to learn more about their disease. To your credit, You have a very engaging and authoritative writing style, which makes it even more important that you ensure the accuracy of the information you provide. Unfortunately your comments about hyperinsulinemia are at least ill-informed and at best outdated. Over 3 years ago, the following study was published: http://atvb.ahajournals.org/cgi/content/abstract/24/2/325<BR/>You'll note that the researchers came to the exact OPPOSITE conclusion that you mentioned in your blog above. Furthermore,<BR/>The United Kingdom Prospective Diabetes Study, which has been published for many years now, makes it very clear that lower blood sugars do more to reduce micro and macro-vascular complications than the method by which those sugars are reduced. Thank you for your blog, please do your homework.<BR/><BR/>DaveAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-16774010.post-16449045441862537882007-03-15T13:26:00.000-04:002007-03-15T13:26:00.000-04:00Hi Scott.....I found out where the Audio was comin...Hi Scott.....I found out where the Audio was coming from every time I loaded your Blog Site. It was from:<BR/> February 12, 2007<BR/>The Role of the Media with Diabetes<BR/>The Audio that was automatically turning on was Osmosis Jones which you have on your Site.BetterCellhttps://www.blogger.com/profile/13667917240368089110noreply@blogger.comtag:blogger.com,1999:blog-16774010.post-84878796246586448422007-03-14T21:51:00.000-04:002007-03-14T21:51:00.000-04:00Thanks for your comments, everyone. Barry, you're...Thanks for your comments, everyone. Barry, you're the first person to mention this issue, and I'm not sure I know what to look for here -- I wonder if its a Macintosh issue? I'll check my template settings, but since no one else has reported the issue, I'm not sure I'll have any luck resolving the issue, but thanks for bringing it to my attention nevertheless.<BR/><BR/>Regards,<BR/>ScottScott Shttps://www.blogger.com/profile/03286529314567223617noreply@blogger.comtag:blogger.com,1999:blog-16774010.post-47636192227754632702007-03-14T19:49:00.000-04:002007-03-14T19:49:00.000-04:00I guess the truth will be told when we see how man...I guess the truth will be told when we see how many of these pens Lilly actually sells, and then the market will have spoken. At the discounted price of $45 or so for the Memoir, that's a chunk of pens. I've yet to see any proposed pricing for the Luxura HD. Granted, both pens incorporate desirable features, but by themselves I don't see that they offer enough bang for the buck. By comparison, the OptiClick pen from Sanofi-Aventis works ok, but its performance is not revolutionary. I have a harder time knocking it, since Sanofi-Aventis didn't expect me to pay for the pen; they just wanted me to use their insulin. Hmmm.....<BR/><BR/>RBAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-16774010.post-86925866679715092772007-03-14T19:22:00.000-04:002007-03-14T19:22:00.000-04:00ScottThank you for this additional information abo...Scott<BR/><BR/>Thank you for this additional information about Lilly's thinking regarding their Memoir pen.<BR/><BR/>Overall I agree that those of us with Type 1 are not getting much coverage due to the constant news about the diabetes epidemic (Type 2 assumed) and the growing numbers in that area.<BR/><BR/>I think there's a good many Type 1 bloggers, and I hope that this may change how the care industry treats the disease.Bernardhttps://www.blogger.com/profile/14936264471078732019noreply@blogger.comtag:blogger.com,1999:blog-16774010.post-57293317233400435902007-03-14T18:47:00.000-04:002007-03-14T18:47:00.000-04:00Hello Scott......Whenever I go to your Website:sst...Hello Scott......Whenever I go to your Website:sstrumello.blogspot.com. an Audio feature automatically comes on that sounds like a review for a movie. Are you aware of this?BetterCellhttps://www.blogger.com/profile/13667917240368089110noreply@blogger.comtag:blogger.com,1999:blog-16774010.post-45097529363216571232007-03-14T18:42:00.000-04:002007-03-14T18:42:00.000-04:00Hello Scott.....I could not send this message to y...Hello Scott.....I could not send this message to you via Email because you do not have that feature enabled on your Site. Whenever I go to your Site :<BR/>sstrumello.blogspot.com, an Audio comes on automatically which sounds like a review for a movie. Are you aware of this?BetterCellhttps://www.blogger.com/profile/13667917240368089110noreply@blogger.com