tag:blogger.com,1999:blog-16774010.post5100665022901207983..comments2024-01-25T17:58:34.297-05:00Comments on Scott's Web Log: New Research Clarifies Distinction Between Different Types of DiabetesScott Shttp://www.blogger.com/profile/03286529314567223617noreply@blogger.comBlogger7125tag:blogger.com,1999:blog-16774010.post-51713835229231613052009-11-16T01:44:21.770-05:002009-11-16T01:44:21.770-05:00Many institutions limit access to their online inf...Many institutions limit access to their online information. Making this information available will be an asset to all.Reaserch Papershttp://researchpaperspot.com/noreply@blogger.comtag:blogger.com,1999:blog-16774010.post-11229661266805790042008-07-15T12:22:00.000-04:002008-07-15T12:22:00.000-04:00Scott, I never thought of it that way. That is ver...Scott, I never thought of it that way. That is very interesting indeed. I we can get some evidence on the topic, this may be an issue worthy of advocacy. If synthetic insulin can be damaging over the long-run, then it's worth fighting for better insulin production.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-16774010.post-68690654594647972282008-07-15T11:41:00.000-04:002008-07-15T11:41:00.000-04:00This is very interesting research, and does appear...This is very interesting research, and does appear to be an explanation of a/the pathway of insulin resistance.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-16774010.post-41324355016133802172008-07-15T11:01:00.000-04:002008-07-15T11:01:00.000-04:00Thanks Brent and David,You both raise interesting ...Thanks Brent and David,<BR/><BR/>You both raise interesting points, and that is that we know there are problems with the insulin structure created in people with type 2 diabetes, and perhaps in some with type 1 also. I suspect that the "folding" process Dr. Weiss described can have a mishap at any number of points in its creation, but at least with endogenous insulin production there is a possibility to produce some perfect molecules and some which aren't -- the one's which aren't perfect cause the beta cells which product them to be the target of inflammation which kills them.<BR/><BR/>The issue of biosynthetic insulin is even more troubling because these products have never been tested (indeed, no such tests existed until recently) to determine if the insulin molecules coming out of Lilly's or Novo's synthetic factories (or anyone else's for that matter) are "perfect" either, but there is a clue that they aren't, largely due to the insulin antibodies present in so many people with type 1 and type 2 diabetes. Its possible that there are some good molecules and some junk regardless of how its made, but the relative and lack of regulatory oversight on biosynthetic insulin is an issue that deserves more attention!Scott Shttps://www.blogger.com/profile/03286529314567223617noreply@blogger.comtag:blogger.com,1999:blog-16774010.post-12365387569665016302008-07-15T10:38:00.000-04:002008-07-15T10:38:00.000-04:00Thanks for posting this, Scott, and taking the tim...Thanks for posting this, Scott, and taking the time to explain it so thoroughly.<BR/><BR/>I recently did an interview with Dr. Michael Weiss, a researcher at Case Western Reserve University. His research is focused on understanding beta cell exhaustion in type 2 diabetics as well. He reached the same conclusion. Our interview covers how the misfolding occurs and how the process might one day be stopped in easy-to-understand terms. <BR/><BR/>Listen to the podcast: <A HREF="http://www.diabetesdaily.com/edelman/2008/06/podcast-understanding-beta-cell-exhaustion-in-type-2-diabetics.php" REL="nofollow">Understanding Beta Cell Exhaustion in Type 2 Diabetics</A>.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-16774010.post-67499407920105032752008-07-15T08:34:00.000-04:002008-07-15T08:34:00.000-04:00This research coming out of Australia at first gla...This research coming out of Australia at first glance appears to be a significant finding regarding the etiology of T1 and T2 diabetes. The significance of the catch-all term “malformed insulin,” used to distinguish apparent difference, becomes the Catch-22. Researchers for a long time have known symptomology for these TWO diseases is characteristically near enough the “same” to allow the two diseases to be lumped together. The problem I see occurring with the approach out of Australia is the fact that no one can really IDENTIFY a perfect insulin molecule. Until we have the technology to differentiate the “perfect” from the “near perfect” in a 3-dimensional manner, like we can fingerprints in a 2-dimensional manner, all we can do is GUESS at the probability of WHY. We have heard in the past that T1 diabetes may be the result of malformed insulin, which in turn causes the autoimmune response. So what’s new about the T2 proposal? Could it be that we know so little about the insulin receptors in the body that perhaps T1 is an insulin-production problem while T2 is an insulin-receiver problem?<BR/><BR/>Just the other day, I went into my local hardware store to have several keys made for my car. Of the three “identical” keys produced from my master—two allowed me to start my car—one didn’t. Of course, since all master keys are made with encoded electronic alarm controls, etc., none of the copies would engage/operate the ‘electronic’ gadgetry. Additionally, the two that did work also set off the car’s alarm system. Suppose that the ‘perfect’ molecule of insulin has all the right stuff, but one amino acid located in the ‘right spot’ is slightly skewed, left or right, from its two-dimensional plane. How does the insulin receptor “see” this molecule if it happens to be located at the point of reception? Unfortunately, diabetics’ heightened immune systems seem to detect DEFAULT much better than most of our scientists understand. <BR/><BR/>This whole study does make one question—at least a little—the veracity of pursuing MORE analog insulins to further confuse the body.<BR/><BR/>--BrentAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-16774010.post-57446043880575493892008-07-14T11:44:00.000-04:002008-07-14T11:44:00.000-04:00Thanks.Very good job of covering the research pape...Thanks.<BR/><BR/>Very good job of covering the research papers and putting it into actual, understandable English.Bennethttps://www.blogger.com/profile/17411395744352827620noreply@blogger.com